George Kambosos will take on Vasiliy Lomachenko for the vacant IBF lightweight title in Perth on Sunday, May 12.
The long-rumoured bout has now been confirmed, with Kambosos set to bring a third world title fight to Australian shores.
Perth's 15,000-capacity RAC Arena is the landing spot for the pair, who are each looking to regain a world title at 135-pounds.
TICKETS: Get your Kambosos vs. Lomachenko tickets here
Having held belts at featherweight, super featherweight and lightweight, two-time Olympic gold medallist Lomachenko was dethroned by Teofimo Lopez in 2020.
Lopez then dropped the unified titles to Kambosos in late 2021.
In his first attempted defence, Kambosos was defeated by Devin Haney in Melbourne, before the American repeated the result in the rematch to retain the undisputed title.
Haney then put those belts on the line against Lomachenko and came away with a close unanimous decision victory.
When he steps into the ring to face Kambosos, Lomachenko, who turns 36 next month, won't have fought since his loss to Haney, which will be just shy of a year out of the ring.
Kambosos, 30, returned from his own fights with Haney against English southpaw Maxi Hughes in July, emerging victorious via majority decision.
Since taking on both Kambosos and Lomachenko, Haney has moved up to super lightweight and claimed a world title there, leaving the belts at 135-lb up for grabs.
MORE: Has Shakur Stevenson retired from boxing for good?
The Kambosos clash, co-promoted by Top Rank, will take place on Sunday afternoon in Australia, to allow for a Saturday night primetime slot on ESPN in America.
Foxtel's pay-per-view channel Main Event will air the bout in Australia, as well as streaming service, Kayo.
In 20 professional bouts, Ukraine's Lomachenko has only fought outside of the US on two occasions.
He was originally slated to face Kambosos in 2022 but opted to help defend his homeland of Ukraine following Russia's invasion.
Organisers have also confirmed two more title fights will feature on the card.
Carlos Cuadras will look to turn back the challenge of Australia's Andrew Moloney when he puts his interim WBC super flyweight belt on the line, while Cherneka Johnson will look to become a two-time world champion when she takes on Nina Hughes for the WBA bantamweight title.